Boris Bastian, MD, PhD

Gerson and Barbara Baker Distinguished Professor of Cancer Biology
Professor of Pathology and Dermatology
+1 415 502-0268
Featured Publications: 

Mutations in the promoter of the telomerase gene TERT contribute to tumorigenesis by a two-step mechanism.

Science (New York, N.Y.)

Chiba K, Lorbeer FK, Shain AH, McSwiggen DT, Schruf E, Oh A, Ryu J, Darzacq X, Bastian BC, Hockemeyer D

The Genetic Evolution of Melanoma from Precursor Lesions.

The New England journal of medicine

Shain AH, Yeh I, Kovalyshyn I, Sriharan A, Talevich E, Gagnon A, Dummer R, North J, Pincus L, Ruben B, Rickaby W, D'Arrigo C, Robson A, Bastian BC

RasGRP3 Mediates MAPK Pathway Activation in GNAQ Mutant Uveal Melanoma.

Cancer cell

Chen X, Wu Q, Depeille P, Chen P, Thornton S, Kalirai H, Coupland SE, Roose JP, Bastian BC

Distinct sets of genetic alterations in melanoma.

The New England journal of medicine

Curtin JA, Fridlyand J, Kageshita T, Patel HN, Busam KJ, Kutzner H, Cho KH, Aiba S, Bröcker EB, LeBoit PE, Pinkel D, Bastian BC

From melanocytes to melanomas.

Nature reviews. Cancer

Shain AH, Bastian BC

Exome sequencing of desmoplastic melanoma identifies recurrent NFKBIE promoter mutations and diverse activating mutations in the MAPK pathway.

Nature genetics

Shain AH, Garrido M, Botton T, Talevich E, Yeh I, Sanborn JZ, Chung J, Wang NJ, Kakavand H, Mann GJ, Thompson JF, Wiesner T, Roy R, Olshen AB, Gagnon A, Gray JW, Huh N, Hur JS, Busam KJ, Scolyer RA, Cho RJ, Murali R, Bastian BC

Mutations in GNA11 in uveal melanoma.

The New England journal of medicine

Van Raamsdonk CD, Griewank KG, Crosby MB, Garrido MC, Vemula S, Wiesner T, Obenauf AC, Wackernagel W, Green G, Bouvier N, Sozen MM, Baimukanova G, Roy R, Heguy A, Dolgalev I, Khanin R, Busam K, Speicher MR, O'Brien J, Bastian BC

Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi.

Nature

Van Raamsdonk CD, Bezrookove V, Green G, Bauer J, Gaugler L, O'Brien JM, Simpson EM, Barsh GS, Bastian BC

MC1R germline variants confer risk for BRAF-mutant melanoma.

Science (New York, N.Y.)

Landi MT, Bauer J, Pfeiffer RM, Elder DE, Hulley B, Minghetti P, Calista D, Kanetsky PA, Pinkel D, Bastian BC

Somatic activation of KIT in distinct subtypes of melanoma.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Curtin JA, Busam K, Pinkel D, Bastian BC